Enhancement of aflatoxin B1 and N-methyl-N'-nitro-N-nitrosoguanidine hepatocarcinogenesis in rainbow trout Salmo gairdneri by 17-B-estradiol and other organic chemicals
نویسندگان
چکیده
منابع مشابه
Enhancement of aflatoxin B1 and N-methy1-N'- nitro-N-nitrosoguanidine hepatocarcinogenesis in rainbow trout Salmo gairdneri by 17-B-estradiol and other organic chemicals*
Twenty-one-day-old rainbow trout Salmo gairdneri embryos were exposed to static solutions of aflatoxin B, (AFB,) (0.5 pprn for 30 min) or N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) (50 ppm for 60 min) to initiate neoplasms of the liver (AFB1 and MNNG) and other organs (MNNG). Ten weeks after the onset of feeding (14 wk after carcinogen exposure) the fish were started on diets containing 500 pp...
متن کاملEnhancement of gastric carcinogenesis in dogs given N-methyl-N'-nitro-N-nitrosoguanidine following vagotomy.
In an attempt to improve the method of induction of gastric cancer in dogs, selective vagotomy without drainage procedure was performed before administration of Nmethyl-N †̃-nitmo-N-nitrosoguanidine(MNNG). Twenty dogs were divided into two groups of 10 dogs (five beagles and five mongrels). The control group received MNNG alone. Dogs of the experimental group were vagotomized 2 months before a...
متن کاملAdaptive response and enhancement of N-methyl-N'-nitro-N-nitrosoguanidine mutagenesis by chloramphenicol in Streptomyces fradiae.
Streptomyces fradiae expressed an adaptive response to treatment with small doses of N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) that caused a reduction in mutagenesis by treatment with larger doses of MNNG. Treatment of S. fradiae with high levels of MNNG in the presence of chloramphenicol caused enhancement of mutagenesis, independent of the adaptive response.
متن کاملEffect of calcium on rat gastric carcinogenesis induced by N-methyl-N'-nitro-N-nitrosoguanidine.
The effect of calcium carbonate (CaCO3) on the initiation of gastroduodenal carcinogenesis induced by N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) was examined under the conditions with and without sodium chloride. Male Wistar rats were given drinking water containing MNNG (100 mg/liter) and one of the following diets during the first 20 weeks ad libitum. Group 1 was given basal diet; group 2, d...
متن کاملReactive Oxygen Species Mediate Epstein-Barr Virus Reactivation by N-Methyl-N’-Nitro-N-Nitrosoguanidine
N-nitroso compounds (NOCs) and Epstein-Barr virus (EBV) reactivation have been suggested to play a role in the development of nasopharyngeal carcinoma (NPC). Although chemicals have been shown to be a risk factor contributing to the carcinogenesis of NPC, the underlying mechanism is not fully understood. We demonstrated recently that N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) enhances the geno...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Diseases of Aquatic Organisms
سال: 1988
ISSN: 0177-5103,1616-1580
DOI: 10.3354/dao005185